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May 20, 2026American Journal of Respiratory and Critical Care Medicine

C57-02 Long-term Outcomes on Hyperpolarized Xenon-129 MRI of Non-critical Covid-19 Infections in New York City

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Authors

ISI M SzablewskiEOE C OelsnerKBK L Buschur

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Overview

Randomized trial assesses pulmonary health in non-critical COVID-19 infections, indicating no long-term lung damage.

Key Points

  • This study aims to evaluate long-term pulmonary sequelae of non-critical COVID-19 infections using hyperpolarized 129Xe MRI.
  • 56 adult participants recruited based on SARS-CoV-2 infection history from New York City, examined 2.7 years post-infection.
  • Hyperpolarized 129Xe MRI, including diffusion weighted imaging and ventilation defect imaging, was conducted on all participants.
  • Statistical methods included t-tests, ANOVA, and regression analyses adjusted for sex, BMI, and age.
  • No significant associations found between 129Xe MRI measures and COVID severity.
  • Significant associations between 129Xe MRI measures and smoking; VDP was 14±11% in ever-smokers versus 5.6±3.3% in never-smokers (P = 0.00002).
  • Age showed significant correlation with ADC (P = 0.00007; r = 0.5) and LmD (P = 0.0005; r = 0.5).

Cite This Study

Szablewski et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5114f03e14405aa9d648https://doi.org/10.1093/ajrccm/aamag162.4445
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