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This study aims to explore how glutamine starvation affects ferroptosis in non-small cell lung cancer (NSCLC).

May 20, 2026NutrientsOpen Access

Glutamine Starvation Induces Ferroptosis in NSCLC via AMPK/PDZD8-Mediated Ferritinophagy

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Randomized trial reveals glutamine starvation drives ferroptosis in NSCLC, suggesting new dietary therapies.

This study aims to explore how glutamine starvation affects ferroptosis in non-small cell lung cancer (NSCLC).
Evaluated glutamine starvation effects in A549 and H460 NSCLC cell lines and SCID mice xenograft models.
Analyzed cell viability, migration, clonogenic capacity, and expression of ferritinophagy and ferroptosis markers.
Manipulated AMPK activity through overexpression and inhibition to uncover mechanistic insights.
Glutamine starvation significantly suppressed tumor growth and reduced cell migration and clonogenicity.
Activated AMPK led to increased PDZD8 expression and modulation of ferritinophagy and ferroptosis markers.
Overexpression of PDZD8 was sufficient to promote ferritinophagy and ferroptosis in NSCLC cells.

Chen et al. (2026) studied this question.

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