Key result
Mild preoperative anxiety before AVR is linked to fewer postoperative complications and lower WBC counts.
Why the study?
To evaluate the association of preoperative anxiety with inflammatory indicators and postoperative complications in patients undergoing scheduled aortic valve replacement surgery.
Does preoperative anxiety affect inflammatory indicators and postoperative complications in patients undergoing scheduled aortic valve replacement?
Cohort (n=73)
Does preoperative anxiety affect inflammatory indicators and postoperative complications in patients undergoing scheduled aortic valve replacement?
Mild preoperative anxiety may be associated with lower postoperative complications and a reduced inflammatory response compared to moderate-severe anxiety in patients undergoing aortic valve replacement.
Does not support altering preoperative anxiety management in aortic valve replacement; leaves open causal links to inflammation and complications.
Objective This study was performed to evaluate the association of preoperative anxiety with inflammatory indicators and postoperative complications in patients undergoing scheduled aortic valve replacement surgery. Methods A prospective cohort study was performed. The Hamilton Anxiety Scale was used to assess preoperative anxiety. The serum white blood cell (WBC) count and concentrations of C-reactive protein, interleukin (IL)-6, and IL-8 were measured 1 day preoperatively and 3 and 7 days postoperatively. Postoperative complications were also recorded. Results Seventy-three patients were included. The incidence of preoperative anxiety was 30.1% (22/73). The payment source was the only independent risk factor for preoperative anxiety. The incidence of postoperative complications was lowest in the mild anxiety group. The WBC count 3 days postoperatively was significantly lower in the mild than moderate-severe anxiety group. The IL-8 concentration 1 day preoperatively was highest in the no anxiety group. Conclusions Mild preoperative anxiety might help to improve clinical outcomes. However, further investigations with more patients are warranted. Patients with different degrees of anxiety may have different levels of inflammatory cytokines.
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Gao et al. (2021) conducted a cohort in Aortic valve replacement (n=73). Preoperative anxiety vs. No anxiety or different degrees of anxiety was evaluated on Inflammatory indicators and postoperative complications. Mild preoperative anxiety in patients undergoing aortic valve replacement was associated with the lowest incidence of postoperative complications and lower postoperative WBC counts.
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