What question did this study set out to answer?

This study aims to evaluate the effect of acetazolamide on REM-predominant obstructive sleep apnea severity and underlying physiological mechanisms.

C21-08 Acetazolamide to Prevent Ventilatory Drive Withdrawal in REM Sleep Apnea: A Randomized Controlled Trial

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial shows acetazolamide reduces apnea hypopnea index in individuals with REM sleep apnea, indicating its potential therapeutic role.

This study aims to evaluate the effect of acetazolamide on REM-predominant obstructive sleep apnea severity and underlying physiological mechanisms.
Randomized, crossover, double-blind design with 11 participants allocated to acetazolamide or placebo.
Community participants with REM-predominant OSA were assessed using polysomnography for apnea hypopnea index and hypoxic burden.
Detailed physiological measurements included diaphragm and genioglossus electromyography following each intervention.
Acetazolamide reduced apnea hypopnea index by 35.5% and hypoxic burden by 35.9% vs. placebo (P < 0.001).
Acetazolamide did not reduce dips in ventilatory drive (P = 0.8) but increased collapsibility and muscle responsiveness (P < 0.001).
Increased ventilation at eupneic drive by +1.4 L/min and raised muscle responsiveness in genioglossus (P = 0.001).

Messineo et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial shows acetazolamide reduces apnea hypopnea index in individuals with REM sleep apnea, indicating its potential therapeutic role.

This study aims to evaluate the effect of acetazolamide on REM-predominant obstructive sleep apnea severity and underlying physiological mechanisms.
Randomized, crossover, double-blind design with 11 participants allocated to acetazolamide or placebo.
Community participants with REM-predominant OSA were assessed using polysomnography for apnea hypopnea index and hypoxic burden.
Detailed physiological measurements included diaphragm and genioglossus electromyography following each intervention.
Acetazolamide reduced apnea hypopnea index by 35.5% and hypoxic burden by 35.9% vs. placebo (P < 0.001).
Acetazolamide did not reduce dips in ventilatory drive (P = 0.8) but increased collapsibility and muscle responsiveness (P < 0.001).
Increased ventilation at eupneic drive by +1.4 L/min and raised muscle responsiveness in genioglossus (P = 0.001).

Messineo et al. (2026) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark