B23-20 Quantitative CT Detects Changes in Parenchymal, Airway and Vascular Features in Familial Pulmonary Fibrosis Relatives With Interstitial Lung Abnormalities
Randomized trial characterizes vascular and airway changes in relatives of familial pulmonary fibrosis patients, suggesting early detection of disease progression.
Key Points
The aim was to characterize airway, vascular, and parenchymal features in first-degree relatives of familial pulmonary fibrosis patients with and without interstitial lung abnormalities.
Analyzed HRCT scans of 227 first-degree relatives from a longitudinal cohort study.
Used unpaired student's T-test to compare qCT parameters between subjects with and without interstitial lung abnormalities.
Employed a fully-automated analysis pipeline with manual quality checks on CT images.
Significant differences noted in total vascular volume normalized to lung volume (p = 0.008) and mean lung density (p = 0.04).
Airway volume normalized to total lung volume trended towards significance (p = 0.099).
Changes in vascular structures, airway volumes, and lung density observed in relatives with interstitial lung abnormalities.