Key result
T2D is linked to upregulated myocardial miR-208a versus non-diabetic IHD, indicating maladaptive cardiac remodeling.
Why the study?
The diabetic heart undergoes remodelling leading to heart failure, but the molecular regulators driving this process remain unknown.
Observational (n=25)
No
p-value: p=<0.0001
Early upregulation of miR-208a drives maladaptive cardiac remodeling in diabetes, and its therapeutic inhibition prevents the hypertrophic response in vitro.
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miR-208a may mediate diabetic cardiac remodeling; animal and in vitro findings leave open therapeutic inhibition.
Rawal et al. (2019) conducted an observational in Type 2 diabetes with ischaemic heart disease (n=25). Type 2 Diabetes vs. Non-diabetic ischaemic heart disease was evaluated on Expression of miR-208a in right atrial appendage and left ventricular biopsy tissues (p=<0.0001). Type 2 diabetes significantly upregulated the expression of cardiac-specific miR-208a in human myocardium compared to non-diabetic ischemic heart disease (p<0.0001), linking it to maladaptive cardiac remodeling.
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