Key result
A factor-analysis-derived inflammation score independently predicted long-term mortality from cancer (HR 1.35, P=0.003) and cardiovascular disease (HR 1.46, P=0.002) over two decades of follow-up.
Why the study?
Do simple indices of inflammation predict long-term mortality from cancer or cardiovascular disease in white males?
Population
1010 white males
Design
Cohort
Follow-up
Mean 18.2-21.9 years
Authors
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May aid long-term risk stratification in white males; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=1,010)
Do simple indices of inflammation predict long-term mortality from cancer or cardiovascular disease in white males?
Effect estimate: HR 1.46
p-value: p=0.002
Simple indices of inflammation, such as WBC, ESR, and globulin levels, are strong, independent long-term predictors of both cancer and cardiovascular mortality.
Godsland et al. (2010) conducted a cohort in Cancer and cardiovascular disease (n=1,010). Inflammation indices (WBC, ESR, serum globulin, inflammation score) was evaluated on Death from any cancer or CVD (HR 1.46, p=0.002). A factor-analysis-derived inflammation score independently predicted long-term mortality from cancer (HR 1.35, P=0.003) and cardiovascular disease (HR 1.46, P=0.002) over two decades of follow-up.
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