Laccase-Shelled Microbubbles for Enzymatic Degradation of Doxorubicin: A Novel Cardioprotective Strategy

Key Points

• To evaluate the efficacy of laccase-shelled microbubbles in degrading doxorubicin and providing cardioprotection.
• Utilized laccase-shelled microbubbles for doxorubicin degradation
• Assessed cardioprotective effects in an experimental model
• Implemented statistical analysis for outcomes.
• Laccase-shelled microbubbles degraded doxorubicin effectively, achieving a degradation rate of 80% within 24 hours
• Cardioprotection was evidenced by a significant reduction in cardiac damage markers (p<0.05)
• Improvement in heart function metrics observed post-treatment, indicating a positive therapeutic outcome.