The Impact of Testosterone on Erectile Function

Erectile function is dependent on the correct balance of vasoactive substances, neurotransmitters, endocrine factors, and tissue fibroelastic properties. Erectile dysfunction (ED) is a multifactorial condition that results from an imbalance of any of the factors that contribute to maintaining proper erectile function. In animal and human studies, hypogonadism has been found to interfere with the proper synthesis and/or release of enzymes as well as the tissue structure and function in the corpora cavernosa leading to ED. Restoring testosterone levels can improve erectile function for hypogonadal men with ED. Combination therapy with testosterone and phosphodiesterase-5 inhibitors has the potential to improve parameters for a greater number of patients struggling with ED who have comorbidities and do not respond to either treatment alone. When used in the appropriate clinical scenario, testosterone therapy can be a safe and effective treatment option for ED.