Key result
Elevated sclerostin correlates with higher LVMI and LVH in stage 3-5 pre-dialysis CKD.
Why the study?
The Dickkopf wingless (Wnt/beta-catenin) signalling pathway is significant in cardiovascular disease, but the relationship between sclerostin and LVMI or LVH in predialysis CKD patients required investigation.
Observational (n=282)
Elevated sclerostin levels in pre-dialysis CKD patients are significantly correlated with increased left ventricular mass index and the presence of left ventricular hypertrophy.
Should not yet change CKD-LVH practice; hypothesis-generating for sclerostin as biomarker or target.
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Durak et al. (2025) conducted an observational in Stage 3-5 predialysis chronic kidney disease (n=282). Sclerostin levels vs. Healthy individuals was evaluated on Relationship between sclerostin and left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH). Elevated sclerostin levels in stage 3-5 pre-dialysis CKD patients were significantly positively correlated with left ventricular mass index and left ventricular hypertrophy.
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