Why the study?
How do left ventricular hypertrophy, oxygen supply, and myocardial lactate production differ between patients with aortic stenosis versus aortic insufficiency?
Population
Patients with left ventricular hypertrophy due to stenosis or insufficiency of the aortic valve, and control…
Comparison
Atrial pacing-induced tachycardia vs Control patients without cardiac disease
Design
Cross-sectional
Authors
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May signal greater ischemia vulnerability in aortic stenosis under stress; leaves open causal links to surgical mortality.
How do left ventricular hypertrophy, oxygen supply, and myocardial lactate production differ between patients with aortic stenosis versus aortic insufficiency?
In chronic aortic valve disease, pacing-induced tachycardia provokes myocardial ischemia (indicated by lactate production) more frequently in aortic stenosis than in aortic insufficiency, which correlates with surgical mortality.
Trenouth et al. (1976) studied this question.
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