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January 25, 2026Journal of Medical Case ReportsOpen Access

Familial clustering of RV dysfunction, atrial tachyarrhythmias, and conduction disease observed across three generations.

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Why the study?

The association of right ventricular dysfunction, atrial tachyarrhythmias, and cardiac conduction system disease is rarely reported in the literature.

Population

A single family presenting with right ventricular dysfunction, atrial tachyarrhythmias, and cardiac conduction system disease

Design

Case report and review of literature

Key result

Familial clustering of right ventricular dysfunction, atrial tachyarrhythmias, and cardiac conduction system disease was observed in seven members of an Egyptian family across three generations.

Authors

MMMohamed MuharramSSSherien SamyASA. E. A. Shaaban

Discussion

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Overview

Suggests heritable isolated right ventricular disease; hypothesis-generating and leaves open genetic mechanisms plus family screening needs.

Study Design

Type

Case Report (n=7)

Multicenter

No

Structured PICO

P
Population
A single family presenting with a triad of right ventricular dysfunction, atrial tachyarrhythmias, and cardiac conduction system disease, with the proband being a 70-year-old Egyptian male with complete heart block, paroxysmal atrial fibrillation, and severe tricuspid regurgitation.
I
Intervention
Surgical tricuspid valve replacement with a tissue valve (in the proband)
O
Outcome
Clinical status, functional capacity, and echocardiographic parameters (tricuspid regurgitation, right ventricular function and dimensions)

Reports a rare familial clustering of right ventricular dysfunction, atrial tachyarrhythmias, and cardiac conduction system disease without left ventricular involvement.

Limitations

  • Lack of genetic testing of the affected family members
  • Unavailability of endomyocardial biopsy

Cite This Study

Muharram et al. (2026) conducted a case report in Right ventricular dysfunction, atrial tachyarrhythmias, and cardiac conduction system disease (n=7). Familial clustering of right ventricular dysfunction, atrial tachyarrhythmias, and cardiac conduction system disease was observed in seven members of an Egyptian family across three generations.

synapsesocial.com/papers/6a0d7b419a2918c675a4e4e0https://doi.org/10.1186/s13256-025-05271-6
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