Key result
IGF-I and insulin stimulated DNA synthesis (P<0.05) and increased angiotensinogen production (P<0.01) in cultured rat vascular smooth muscle cells, effects that were blocked by captopril.
Why the study?
Do insulin and IGF-I stimulate angiotensinogen production and growth in cultured rat vascular smooth muscle cells?
Population
Aortic vascular smooth muscle cells (VSMC) derived from male Sprague-Dawley rats
Comparison
Insulin and insulin-like growth factor-I, with… vs Control (untreated cells)
Design
Preclinical
Authors
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Suggests mechanism linking insulin resistance to vascular hypertrophy; leaves open human relevance and therapeutic implications.
Do insulin and IGF-I stimulate angiotensinogen production and growth in cultured rat vascular smooth muscle cells?
p-value: p=<0.05
Insulin and IGF-I stimulate angiotensinogen production and growth in vascular smooth muscle cells, suggesting a mechanism for vascular hypertrophy in insulin resistance.
Kamide et al. (2000) studied Vascular hypertrophy in hypertension and insulin resistance. IGF-I and insulin vs. Control (with or without captopril or alphaIR3) was evaluated on DNA synthesis (3H-thymidine uptake) and angiotensinogen production (p=<0.05). IGF-I and insulin stimulated DNA synthesis (P<0.05) and increased angiotensinogen production (P<0.01) in cultured rat vascular smooth muscle cells, effects that were blocked by captopril.
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