Key result
Occult LV dysfunction in Ebstein anomaly is linked to ~28% lower cardiac output and reduced GFR.
Why the study?
LVGLS can detect early LV systolic dysfunction, but its application had not been studied in Ebstein anomaly.
Does occult left ventricular dysfunction detected by LVGLS associate with worse hemodynamics, end-organ dysfunction, and suboptimal postoperative LV reverse remodeling in adults undergoing Ebstein anomaly repair?
Cohort (n=371)
Does occult left ventricular dysfunction detected by LVGLS associate with worse hemodynamics, end-organ dysfunction, and suboptimal postoperative LV reverse remodeling in adults undergoing Ebstein anomaly repair?
Absolute Event Rate: 2.1% vs 2.9%
p-value: p=<0.001
In adults with Ebstein anomaly undergoing tricuspid valve surgery, abnormal LVGLS identifies occult LV systolic dysfunction which is associated with worse hemodynamics, end-organ dysfunction, and suboptimal postoperative reverse remodeling.
May prompt intensified monitoring in Ebstein anomaly; leaves open whether LVGLS-guided care improves remodeling.
Background: Left ventricular global longitudinal strain (LVGLS) can detect early phases of LV systolic dysfunction, but its application has not been studied in Ebstein anomaly. We hypothesized that LVGLS can detect early phases of LV systolic dysfunction and that patients with occult LV systolic dysfunction will have worse hemodynamics, end-organ dysfunction, and suboptimal postoperative LV reverse remodeling after tricuspid valve surgery in comparison to patients with normal LV systolic function. Methods: In this retrospective cohort study, 371 Ebstein patients that underwent tricuspid valve surgery were divided into 3 groups: normal LV systolic function (normal LVGLS and LV ejection fraction; n=244, 77%), occult LV systolic dysfunction (abnormal LVGLS with normal LV ejection fraction; n=44, 14%), and overt LV systolic dysfunction (abnormal LVGLS and LV ejection fraction; n=27, 9%). Results: Compared with the normal LV function group, the occult group had smaller LV volume and cardiac output (2.1±0.4 versus 2.9±0.6 L/min per m 2 , P <0.001), worse end-organ dysfunction (glomerular filtration rate, 78±14 versus 91±18 mL/min per 1.73 m 2 , P =0.01), and suboptimal postoperative LV reverse remodeling. Although both the occult and overt groups had a similar degree of end-organ dysfunction (glomerular filtration rate, 78±14 versus 82±16 mL/min per 1.73 m 2 , P =0.3), the occult group was less likely to be on heart failure therapy (48% versus 96%, P <0.001). Conclusions: Abnormal LVGLS was associated with suboptimal postoperative LV reverse remodeling. These data suggest that LVGLS can potentially be used for risk stratification and provides a foundation for further studies to determine whether optimal heart failure therapy or tricuspid valve intervention can improve outcomes for LV systolic dysfunction in patients with Ebstein anomaly.
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Egbe et al. (2021) conducted a cohort in Ebstein anomaly (n=371). Occult LV systolic dysfunction vs. Normal LV systolic function was evaluated on Cardiac output (L/min per m2) (p=<0.001). Occult LV systolic dysfunction in Ebstein anomaly patients was associated with lower cardiac output (2.1 vs 2.9 L/min/m2, P<0.001) and worse glomerular filtration rate (78 vs 91 mL/min/1.73m2, P=0.01).
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