Key result
Exosomes may protect ischemic myocardium by promoting angiogenesis and inhibiting fibrosis, apoptosis, and pyroptosis.
Why the study?
Traditional treatments for ischemic heart disease have limitations, including drug resistance, side effects, vascular damage, and infection risk, prompting the need to explore new cell-free therapies such as exosomes from different sources.
This review highlights the preclinical evidence supporting exosomes as a promising cell-free therapeutic strategy for myocardial ischemia.
Answers are grounded in this paper and cite their sources.
Exosome therapy for myocardial ischemia remains investigational; leaves open clinical translation pending randomized human trials.
Ischemic heart disease refers to the imbalance between the supply and demand of myocardial blood; it has various causes and results in a class of clinical diseases characterized by myocardial ischemia (MI). In recent years, the incidence of cardiovascular disease has become higher and higher, and the number of patients with ischemic heart disease has also increased year by year. Traditional treatment methods include drug therapy and surgical treatment, both of which have limitations. The former maybe develop risks of drug resistance and has more significant side effects, while the latter may damage blood vessels and risk infection. At this stage, a new cell-free treatment method needs to be explored. Many research results have shown that exosomes from different cell sources can protect the ischemic myocardium via intercellular action methods, such as promoting angiogenesis, inhibiting myocardial fibrosis, apoptosis and pyroptosis, and providing a new basis for the treatment of MI. In this review, we briefly introduce the formation and consequences of myocardial ischemia and the biology of exosomes, and then focus on the role and mechanism of exosomes from different sources in MI. We also discuss the role and mechanism of exosomes pretreated with Chinese and Western medicines on myocardial ischemia. We also discuss the potential of exosomes as diagnostic markers and therapeutic drug for MI.
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Yan et al. (2024) conducted a review in Myocardial ischemia. Exosomes was evaluated. Exosomes from different cell sources show potential to protect the ischemic myocardium by promoting angiogenesis and inhibiting myocardial fibrosis, apoptosis, and pyroptosis.
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