Key result
Functional overload of rat plantaris muscle increased beta-MHC promoter activity, an effect that was abolished by mutation of the proximal MCAT (betae3) site.
The proximal MCAT (betae3) site functions as a putative functional overload-responsive element in the rat beta-MHC gene promoter.
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Should not inform clinical practice; leaves open the MCAT site's role in human beta-MHC regulation under overload.
Giger et al. (2002) studied Functional overload in rat plantaris muscle. Functional overload and injection of beta-MHC promoters vs. Control plantaris muscles was evaluated on Reporter activities of beta-MHC promoters and complex formation of the betae3 probe. Functional overload of rat plantaris muscle increased beta-MHC promoter activity, an effect that was abolished by mutation of the proximal MCAT (betae3) site.
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