Key result
Oleic acid-induced NOX4 requires ANGPTL4 to drive dyslipidemia-associated colorectal cancer metastasis.
Why the study?
Does oleic acid promote colorectal cancer metastasis through NOX4 and ANGPTL4?
Does oleic acid promote colorectal cancer metastasis through NOX4 and ANGPTL4?
Oleic acid promotes colorectal cancer metastasis via ANGPTL4-dependent NOX4 induction and ROS production, linking hyperlipidemia to cancer progression.
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May link dyslipidemia to CRC metastasis in models; leaves open whether ANGPTL4/NOX4 targeting alters human outcomes.
Shen et al. (2020) studied this question. Oleic acid-induced NOX4 depends on ANGPTL4 expression to promote colorectal cancer metastasis, suggesting both as potential therapeutic targets for dyslipidemia-associated CRC.
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