ChatGPT-4o and OpenAI-o1: A Comparative Analysis of Its Accuracy in Refractive Surgery

Background: To assess the accuracy of ChatGPT-4o and OpenAI-o1 in answering refractive surgery questions from the AAO BCSC Self-Assessment Program and to evaluate whether their performance could meaningfully support clinical decision making, we compared the models with 1983 ophthalmology residents and clinicians. Methods: A randomized, questionnaire-based study was conducted with 228 text-only questions from the Refractive Surgery section of the BCSC Self-Assessment Program. Each model received the prompt, “Please provide an answer to the following questions.” Accuracy was measured as the proportion of correct answers and reported with 95 percent confidence intervals. Differences between groups were assessed with the chi-squared test for independence and pairwise comparisons. Results: OpenAI-o1 achieved the highest score (91.2%, 95% CI 87.6–95.0%), followed by ChatGPT-4o (86.4%, 95% CI 81.9–90.9%) and the average score from 1983 users of the Refractive Surgery section of the BCSC Self-Assessment Program (77%, 95% CI 75.2–78.8%). Both language models significantly outperformed human users. The five-point margin of OpenAI-o1 over ChatGPT-4o did not reach statistical significance (p = 0.1045) but could represent one additional correct decision in twenty clinically relevant scenarios. Conclusions: Both ChatGPT-4o and OpenAI-o1 significantly outperformed BCSC Program users, demonstrating a level of accuracy that could augment medical decision making. Although OpenAI-o1 scored higher than ChatGPT-4o, the difference did not reach statistical significance. These findings indicate that the “advanced reasoning” architecture of OpenAI-o1 offers only incremental gains and underscores the need for prospective studies linking LLM recommendations to concrete clinical outcomes before routine deployment in refractive-surgery practice.