Key result
Higher D-dimer to creatinine ratio strongly predicts higher coronary Gensini scores in STEMI patients.
Why the study?
To evaluate whether the D-dimer to creatinine ratio could serve as a new clinical biomarker and explore its association with STEMI and Gensini score.
Is the D-dimer to creatinine ratio associated with the Gensini score in STEMI patients?
Observational (n=347)
Is the D-dimer to creatinine ratio associated with the Gensini score in STEMI patients?
Answers are grounded in this paper and cite their sources.
The D-dimer to creatinine ratio is a novel biomarker that positively correlates with the angiographic severity of coronary artery disease (Gensini score) in patients presenting with STEMI.
Objective We propose for the first time that D-dimer to creatinine ratio (DCR) may serve as a new clinical biomarker and explore its association with ST-segment elevation myocardial infarction (STEMI). Methods 347 STEMI patients with complete D-dimer and creatinine were included in the analysis. According to the median of DCR value, patients were divided into the lower DCR group (DCR < 1.402, n = 173) and the higher DCR group (DCR ≥ 1.402, n = 174), and the differences between the two groups were compared. In addition, patients were divided into four groups according to the quartiles of Gensini score: Group 1(Gensini score ≤ 34, n = 88); Group 2(34 < Gensini score ≤ 65, n = 88); Group 3(65 < Gensini score ≤100, n = 87); Group 4(Gensini score ＞100, n = 84). Multivariate linear and multivariate logistic regression analyzes were performed to determine independent predictors of the Gensini score. Results High DCR group had higher Gensini score compared with the low DCR group ( P < .05). DCR was positively correlated with Gensini score (r = 0.493, P < .001). Multiple linear regression analysis showed that Previous MI (r = 11.312, P = .035) and DCR (r = 5.129, P < .001) were independent risk factors associated with the Gensini score. Multivariate logistic regression analysis showed that, compared to Group 1, DCR was an independent risk factor in Group 2, Group 3, Group 4 ( P < .001). Conclusions As a new and useful clinical biomarker, DCR was positively correlated with coronary Gensini score in STEMI patients.
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Yang et al. (2022) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=347). D-dimer to creatinine ratio (DCR) vs. Lower DCR (< 1.402) was evaluated on Gensini score (r = 0.493, p=<.001). D-dimer to creatinine ratio (DCR) was positively correlated with coronary Gensini score in STEMI patients (r = 0.493, P < .001) and was an independent predictor of the score.
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