Deciphering Osteosarcopenia through the hallmarks of aging

Osteosarcopenia is a major driver of functional loss and a risk factor for falls, fractures, disability and mortality in older adults, urgently requiring the development of effective interventions to address it. The hallmarks of aging provide a theoretical and practical framework that allows for the structured organization of current knowledge and the planning of new development lines. This article comprehensively reviews the currently available literature on the role of the Hallmarks of Aging in the development of osteosarcopenia, thereby offering a panoramic view of the state of the art and knowledge gaps in this field. • Osteosarcopenia is defined as the concomitant occurrence of osteopenia/osteoporosis and sarcopenia • Osteosarcopenia is associated to multiple adverse outcomes • Alterations in most of the Hallmarks of Aging are associated with muscle and bone loss • A geroscience approach could target several hallmarks of aging to simultaneously improve muscle and bone mass and function.