What question did this study set out to answer?

To determine whether a novel correlation dimension algorithm applied to heartbeat intervals can sensitively detect myocardial ischemia and prospectively predict impending ventricular fibrillation.

April 1, 1991Circulation ResearchOpen Access

Correlation dimension of heartbeat intervals is reduced in conscious pigs by myocardial ischemia.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Myocardial ischemia (n=8). Intervention: Acute occlusion of the left anterior descending coronary artery vs. Baseline (control). Primary outcome: Correlation dimension of heartbeat intervals (point-D2) (p=<0.01).

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Key result

Acute myocardial ischemia in conscious pigs reduced the correlation dimension of heartbeat intervals (point-D2) from a control mean of 2.50 to 1.07 preceding ventricular fibrillation (p<0.01).

Population

8 conscious pigs

Comparison

Acute occlusion of the left anterior descending… vs Control state (baseline before occlusion)

Design

Preclinical

Authors

JSJ. E. SkinnerStarship Children's Health CCClara CarpeggianiCluster in Biomedicine CLCarole E. LandismanHarvard University

Discussion

Member takes

Implication

Point-D2 reduction precedes VF in porcine ischemia; hypothesis-generating for human arrhythmia monitoring.

Key Points

To determine whether a novel correlation dimension algorithm applied to heartbeat intervals can sensitively detect myocardial ischemia and prospectively predict impending ventricular fibrillation.
Developed and validated a 'point-D2' algorithm designed to estimate correlation dimension accurately in finite time-series data.
Analyzed RR intervals in conscious pigs (N=8) subjected to acute total or partial (50% to 90% blood flow reduction) occlusion of the left anterior descending coronary artery.
Total coronary occlusion reduced point-D2 from a baseline mean of 2.50 ± 0.81 to 1.58 ± 0.64 during the first minute of ischemia (p < 0.01) and to 1.07 ± 0.18 in the minute directly preceding ventricular fibrillation (p < 0.01).
Partial coronary occlusions decreasing blood flow by 50% to 90% produced point-D2 reductions of 25% to 30% relative to control (p < 0.01).
A simultaneous collapse of both the mean point-D2 and its standard deviation to 1.07 ± 0.18 occurred in 100% of cases exclusively during the final minutes prior to ventricular fibrillation.

Structured PICO

Population

8 conscious pigs

Intervention

Acute occlusion of the left anterior descending coronary artery (and partial occlusions)

Comparator

Control state (baseline before occlusion)

Outcome

Change in point-D2 (correlation dimension of RR intervals)surrogate

Main Result

Absolute Event Rate: 1.07% vs 2.5%

p-value: p=<0.01

The point-D2 algorithm for estimating the correlation dimension of RR intervals detects significant reductions during acute myocardial ischemia preceding ventricular fibrillation in a porcine model.

Cite This Study

Skinner et al. (1991) studied Myocardial ischemia (n=8). Acute occlusion of the left anterior descending coronary artery vs. Baseline (control) was evaluated on Correlation dimension of heartbeat intervals (point-D2) (p=<0.01). Acute myocardial ischemia in conscious pigs reduced the correlation dimension of heartbeat intervals (point-D2) from a control mean of 2.50 to 1.07 preceding ventricular fibrillation (p<0.01).

synapsesocial.com/papers/6a0e1aaa370e1ecbafd08b9c https://doi.org/10.1161/01.res.68.4.966

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Correlation dimension of heartbeat intervals is reduced in conscious pigs by myocardial ischemia.

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Correlation dimension of heartbeat intervals is reduced in conscious pigs by myocardial ischemia.

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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