Ninety-six schizophrenic patients participated in a double-blind, crossover study of the efficacy of trifluoperazine and tranylcypromine therapy alone and in combination. Pseudoneurotic patients had a statistically significant response to tranylcypromine; paranoid (chronic undifferentiated) patients responded best to the combination therapy. The authors urge the use of computer-derived profiles of patients' symptom clusters rather than their diagnoses to ensure selection of the optimum drug therapy.
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HEDBERG et al. (1971) studied this question.
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