Key result
A genome-wide scan in Dutch families with familial combined hyperlipidemia revealed significant linkage of systolic blood pressure to a locus on chromosome 4p (lod score 4.6 after adjustment).
Population
18 Dutch families exhibiting familial combined hyperlipidemia
Design
Cross-sectional
Authors
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Does not alter hypertension management; leaves open replication of the 4p linkage in broader populations.
Observational
Effect estimate: LOD 4.6
A genome-wide scan in Dutch families with familial combined hyperlipidemia identified a significant linkage locus for systolic blood pressure on chromosome 4p.
Allayee et al. (2001) conducted an observational in Familial combined hyperlipidemia and blood pressure variation. Genome-wide scan was evaluated on Linkage to systolic blood pressure (LOD 4.6). A genome-wide scan in Dutch families with familial combined hyperlipidemia revealed significant linkage of systolic blood pressure to a locus on chromosome 4p (lod score 4.6 after adjustment).
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