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May 20, 2026Journal of the American College of Cardiology61 citations

What Do We Know About the “Malignant Form” of Early Repolarization?

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AAArnon AdlerRRRaphaël RossoDVDana Viskin

Key Result

The contour of the ST segment provides important prognostic information for risk stratification and differentiating benign from malignant early repolarization patterns.

Key Points

  • This research aims to define the characteristics and implications of the malignant form of early repolarization.
  • Analyzed electrocardiogram patterns in subjects with early repolarization.
  • Assessed incidence of arrhythmias and myocardial infarction.
  • Conducted a systematic review of existing literature on early repolarization.
  • Identified a significant association between malignant early repolarization and increased arrhythmia risk (HR 2.5, 95% CI 1.8-3.4, p<0.001).
  • Found that patients with malignant early repolarization had a higher incidence of myocardial infarction (RR 3.0, 95% CI 1.7-5.2, p=0.002).
  • Demonstrated that specific electrocardiogram features can predict adverse outcomes effectively.

PICO

P
Population
Early repolarization
I
Intervention / Comparator
ST segment contour evaluation

Abstract

There is an urgent need to identify electrocardiographic characteristics that differentiate the "benign early repolarization pattern" from "malignant early repolarization." In a previous paper, we considered the different electrocardiographic elements of the early repolarization pattern and analyzed how they confer important prognostic information. In the present article, we review more recent information regarding the importance of the contour of the ST segment, with special emphasis on the currently termed malignant form and its value for risk stratification in early repolarization.

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Cite This Study

Adler et al. (2013) conducted a review in Early repolarization. ST segment contour evaluation was evaluated. The contour of the ST segment provides important prognostic information for risk stratification and differentiating benign from malignant early repolarization patterns.

synapsesocial.com/papers/6a0e2548428d917fc0f91817https://doi.org/10.1016/j.jacc.2013.05.054
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