Replacing the anomeric C atom of 2-deoxy-O-glucose with an N atom and the ring O atom with a C atom leads to 1, the most potent β-glycosidase inhibitor known to date. This synthetic monosaccharide derivative also inhibits other glucosidases better than naturally occurring sugar derivatives in which only the O atom in the ring is exchanged for an N atom.
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Jespersen et al. (1994) studied this question.
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