Key result
Plasma von Willebrand factor levels were the strongest determinant of platelet accumulation on type 1 fibrillar collagen in microfluidic flow assays, showing positive correlation at all wall shear rates.
Population
104 healthy donors
Design
Cross-sectional
Authors
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VWF levels may inform normal ranges for microfluidic platelet assays; leaves open validation in patients with thrombotic or bleeding disorders.
Observational (n=104)
No
In healthy donors, von Willebrand factor levels are the strongest determinant of platelet accumulation in microfluidic flow assays, which may help establish normal ranges for clinical application.
Neeves et al. (2013) conducted an observational in Healthy volunteers (n=104). Microfluidic flow assay (MFA) was evaluated on Platelet surface coverage (SC). Plasma von Willebrand factor levels were the strongest determinant of platelet accumulation on type 1 fibrillar collagen in microfluidic flow assays, showing positive correlation at all wall shear rates.
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