Estimating oxygen consumption using a formula based on the left ventricular pressure-volume area and body surface area correlated strongly with thermodilution-measured cardiac output (r=0.93).
Observational (n=10)
Does estimating oxygen consumption based on the left ventricular pressure-volume area accurately estimate cardiac output compared to thermodilution in patients undergoing right cardiac catheterization?
A novel formula based on the left ventricular pressure-volume area and body surface area provides a highly correlated alternative to thermodilution for estimating cardiac output.
Effect estimate: r=0.93
Use of a majority of structural variables (age, sex, height) to estimate oxygen consumption in the calculation of cardiac output (CO) by the Fick principle does not account for changes in physiological conditions. To improve this limitation, oxygen consumption was estimated based on the left ventricular pressure-volume area. A pilot study with 10 patients undergoing right cardiac catheterization showed that this approach was successful to estimate CO (r=0,73, vs. thermodilution measured CO). Further essays changing end-diastolic-volume in the pressure-volume area formula by body weight or body surface area showed that this last yielded the best correlation with the thermodilution measured CO (slope=1, ordinate =0.01 and r=0.93). These preliminary results indicate that use of a formula originated from the pressure-volume-area concept is a good alternative to estimate oxygen consumption for CO calculation.
Negroni et al. (Sun,) conducted a observational in Patients undergoing right cardiac catheterization (n=10). Oxygen consumption estimation based on left ventricular pressure-volume area vs. Thermodilution measured cardiac output was evaluated on Correlation with thermodilution measured cardiac output (r=0.93). Estimating oxygen consumption using a formula based on the left ventricular pressure-volume area and body surface area correlated strongly with thermodilution-measured cardiac output (r=0.93).