Key result
Understanding the mechanisms by which cardiac loading conditions regulate myocardial biology offers prospects for elucidating cardiocyte adaptation at the molecular level.
This review highlights the evolving understanding of how cardiac loading conditions regulate myocardial biology and the transition from compensated hypertrophy to heart failure.
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May guide targeted research on load-induced remodeling; leaves open clinical translation to heart failure therapies.
George Cooper (1987) conducted a review in Myocardial hypertrophy. Understanding the mechanisms by which cardiac loading conditions regulate myocardial biology offers prospects for elucidating cardiocyte adaptation at the molecular level.
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