Key result
Modified-CHADS2 outperforms guideline-endorsed CHA2DS2-VASc in discriminating ischemic stroke risk.
Why the study?
Multiple risk scores to predict ischaemic stroke in patients with AF have been developed, prompting a systematic review of these scores, their validations, updates, methodological quality, and pooled predictive performance.
Do newer stroke risk scores provide better discrimination for ischemic stroke than the CHA2DS2-VASc score in patients with atrial fibrillation?
Meta-Analysis (n=6,267,728)
Do newer stroke risk scores provide better discrimination for ischemic stroke than the CHA2DS2-VASc score in patients with atrial fibrillation?
Effect estimate: c-statistic 0.715 (95% CI 0.674-0.754)
Newer stroke risk scores, particularly the modified-CHADS2, demonstrate superior discrimination for ischemic stroke in atrial fibrillation compared to the widely used CHA2DS2-VASc score.
No takes yet. Share an insight, caveat, or question.
Newer scores may refine AF stroke risk stratification; challenges guideline preference for CHA2DS2-VASc.
Endt et al. (2022) conducted a meta-analysis in Atrial fibrillation (n=6,267,728). Stroke risk scores (e.g., modified-CHADS2, CHA2DS2-VASc) was evaluated on Discriminatory ability (pooled c-statistic) for ischaemic stroke (c-statistic 0.715, 95% CI 0.674-0.754). Newer risk scores like the modified-CHADS2 demonstrated better discrimination for ischaemic stroke (c-statistic 0.715; 95% CI 0.674-0.754) compared to the guideline-endorsed CHA2DS2-VASc (0.644).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: