June 1, 2001Stroke
Safety of Intra-Arterial Thrombolysis in the Postoperative Period
Why the study?
Is intra-arterial thrombolysis safe for treating strokes in the postoperative period?
Population
36 patients who experienced a stroke within 2 weeks of surgery
Design
Case_series
Authors
Discussion
Loading...
Member takes
Implication
May heighten major bleeding risk after craniotomy; leaves open safety of intra-arterial thrombolysis for postoperative stroke.
Structured PICO
Is intra-arterial thrombolysis safe for treating strokes in the postoperative period?
P
Population
36 patients (median age 71.5 years) who experienced a stroke within 2 weeks of surgery (including open heart, carotid endarterectomy, craniotomy, and others)
I
Intervention
Intra-arterial thrombolysis (tissue plasminogen activator or urokinase)
O
Outcome
Safety (surgical site bleeding, intracranial bleeding, and mortality rates)safety
Intra-arterial thrombolysis for postoperative stroke carries a 25% risk of bleeding, which is usually minor, but should be avoided in intracranial surgery patients due to fatal major bleeding risks.
Cite This Study
Chalela et al. (2001) studied this question.