What question did this study set out to answer?

This review aims to assess the effectiveness of calcium antagonists in reducing death or dependency following acute ischemic stroke.

Calcium antagonists for acute ischemic stroke

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Randomized trials investigate calcium antagonists' impact on death or dependency after acute ischemic stroke, indicating no significant benefit.

This review aims to assess the effectiveness of calcium antagonists in reducing death or dependency following acute ischemic stroke.
Randomized trials comparing calcium antagonists with control in patients with acute ischemic stroke were analyzed.
Data were extracted by two authors from 46 trials, with 28 included (7521 patients).
Intention-to-treat analyses were performed on outcomes related to death or dependency.
No significant effect of calcium antagonists on poor outcome (OR 1.07, 95% CI 0.97/1.18) at follow-up was found.
Intravenous administration was linked to a higher incidence of poor outcomes compared to oral administration.
The highest doses of nimodipine were associated with poorer outcomes, and administration within 12 hours increased poor outcomes, primarily due to i.v. administration effects.

Horn et al. (2000) studied this question.

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Randomized trials investigate calcium antagonists' impact on death or dependency after acute ischemic stroke, indicating no significant benefit.