A novel hybrid MRI technique combining DANTE tissue tagging and phase-contrast imaging enables in vivo measurement of 3D myocardial wall motion and regional strain.
May enable detailed strain research; leaves open clinical validation and standardization.
Characterization of myocardial stress and strain is necessary for a complete understanding of myocardial function. The precise quantification of regional myocardial strain is complicated by its time-varying pattern and regional variation resulting from the anisotropy of the myocardium and by complex torsional and shortening motions of the heart during the cardiac cycle. The authors have developed a technique for point-specific tracking of myocardial motion along all three axes in a constant selected section of myocardium by combining prospective section selection with in-plane DANTE (delays alternating with nutations for tailored excitation) tissue tagging and phase-contrast detection of motion perpendicular to the image plane. With this technique, it is possible to determine point-specific myocardial strain values in vivo.
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Perman et al. (1995) studied this question.
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