Why the study?
Anatomic variations of the vein of Marshall may influence the procedural efficacy of ethanol infusion into the vein of Marshall combined with catheter ablation to achieve bidirectional mitral isthmus block.
The efficacy of ethanol infusion into the vein of Marshall is dependent on local anatomy, and complementary epicardial ablation may be necessary to achieve complete mitral isthmus block when anatomy restricts ethanol delivery.
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May warrant adjunctive proximal VOM epicardial ablation after failed EIVOM; leaves open need for prospective validation in larger cohorts.
BACKGROUND: Ethanol infusion into the vein of Marshall (EIVOM), combined with radiofrequency catheter ablation, has been shown to facilitate atrial fibrillation management and achieve bidirectional mitral isthmus (MI) block. However, the anatomic variations of vein of Marshall (VOM) may influence procedural efficacy and should be considered. CASE SUMMARY: A 59-year-old man with persistent atrial fibrillation underwent radiofrequency catheter ablation with the 2C3L (pulmonary vein isolation and linear ablations across the mitral isthmus, left atrial rooftop, and cavotricuspid isthmus) strategy. Despite adequate endocardial ablation and conventional epicardial ablation via the coronary sinus, recurrent peri-mitral flutter developed. EIVOM was subsequently attempted to reinforce the MI block but proved insufficient. Finally, targeted intracoronary sinus epicardial ablation at the proximal VOM terminated the flutter and achieved durable bidirectional block. DISCUSSION: Although EIVOM has proven value in facilitating MI block, its anatomy-dependent efficacy necessitates comprehensive consideration evaluation in clinical practice. TAKE-HOME MESSAGE: The effectiveness of EIVOM depends on VOM anatomy, and meticulous extra epicardial ablation may be required to achieve complete MI block.
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Zheng et al. (2025) studied this question.
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