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February 1, 1997AJP Heart and Circulatory Physiology41 citations

beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts

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Population

Phospholamban (PLB)-knockout and wild-type mouse hearts

Comparison

Isoproterenol perfusion vs Wild-type hearts

Design

Preclinical

Authors

ÉKÉva KissIÉIstván ÉdesYSYoji Sato

Discussion

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Overview

Points to post-phosphorylation mechanisms in PLB-knockout contractile deficits; leaves open translation to human heart failure.

Structured PICO

P
Population
Phospholamban (PLB)-knockout and wild-type mouse hearts
I
Intervention
Isoproterenol perfusion
C
Comparator
Wild-type hearts
O
Outcome
Tissue cAMP levels and degree of phosphorylation of troponin I, C protein, and the 21-kDa microsomal proteinsurrogate

The attenuation of beta-adrenergic contractile responses in PLB-knockout hearts is not caused by altered beta-adrenergic signal transduction or phosphorylation of key myofibrillar and sarcolemmal proteins.

Cite This Study

Kiss et al. (1997) studied this question.

synapsesocial.com/papers/6a0e9ece25c30b2cc7f99df0https://doi.org/10.1152/ajpheart.1997.272.2.h785
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