Venular alpha-adrenergic constrictions are insensitive to hypoxia-induced inhibition, likely due to a paucity of KATP channels on venular smooth muscle.
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Hypoxia may selectively blunt arteriolar alpha-2 tone in this model; leaves open whether venular alpha-AR insensitivity extends to human microvascular regulation.
Leech et al. (1996) studied this question.
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