April 1, 1984The Journal of General PhysiologyOpen Access

Phosphorylation of C-protein in intact amphibian cardiac muscle. Correlation between 32P incorporation and twitch relaxation.

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Population

Intact amphibian cardiac muscle

Comparison

Isoproterenol and Carbamylcholine, and changing… vs Control conditions (baseline)

Design

Preclinical

Authors

HHH. Criss HartzellElectrophysiology

Discussion

Member takes

Implication

Supports C-protein phosphorylation as a regulator of cardiac relaxation in amphibians; leaves open its role in mammalian hearts and clinical implications.

Structured PICO

Population

Intact amphibian cardiac muscle

Intervention

Isoproterenol (1 microM) and Carbamylcholine (0.5 microM), and changing beat frequency

Comparator

Control conditions (baseline)

Outcome

C-protein phosphorylation (measured by 32P incorporation) and rate of relaxation of twitch tensionsurrogate

C-protein phosphorylation levels correlate with the rate of twitch relaxation in amphibian cardiac muscle, suggesting it sets boundaries for relaxation regulation.

Cite This Study

H. Criss Hartzell (1984) studied this question.

synapsesocial.com/papers/6a0e9ece25c30b2cc7f99e02 https://doi.org/10.1085/jgp.83.4.563

View Full Paper

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Bookmark

Implication

Supports C-protein phosphorylation as a regulator of cardiac relaxation in amphibians; leaves open its role in mammalian hearts and clinical implications.

Phosphorylation of C-protein in intact amphibian cardiac muscle. Correlation between 32P incorporation and twitch relaxation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phosphorylation of C-protein in intact amphibian cardiac muscle. Correlation between 32P incorporation and twitch relaxation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider