The Prognostic Value of Circulating Stem Cells Expressing PD-L1 in Patients with Hepatocellular Carcinoma

Dhruvajyoti Roy; Elsie Oppermann; Thomas Vogl; Ibrahim Büdeyri; Dmitry Shapiro; Benjamin Struecker; Christian Rolfo; Nada Abedin; Vladimir Zharov; Andreas Schnitzbauer; Andreas Pascher; Wolf Bechstein; Markus Zimmermann; Mazen Juratli

doi:10.2147/jhc.s598753

May 1, 2026Journal of Hepatocellular CarcinomaOpen Access

The Prognostic Value of Circulating Stem Cells Expressing PD-L1 in Patients with Hepatocellular Carcinoma

View Full Paper

Ask AI

Bookmark

Share

Key Points

To evaluate the prognostic significance of PD-L1+ circulating stem cells in predicting recurrence-free and overall survival in hepatocellular carcinoma patients after surgery.
Analyzed PD-L1+ circulating stem cells in 27 hepatocellular carcinoma patients before and after surgery at set intervals.
Monitored tumor recurrence biannually using alpha-fetoprotein measurements and imaging techniques.
Compared findings with control groups including benign liver disease patients, non-HCC malignancies, and healthy donors.
Before surgery, 29.7% of patients had detectable PD-L1+ circulating stem cells.
Postoperative frequency dropped to 22.3%, then significantly rose to 85% at six months and 88% at twelve months (p<0.001).
Correlation established between higher PD-L1+ CSC frequency and poorer recurrence-free survival and overall survival.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Assesses PD-L1+ circulating stem cells as prognostic biomarkers for recurrence-free survival and overall survival in hepatocellular carcinoma patients, suggesting potential...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Roy et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea074be05d6e3efb5f3e2 https://doi.org/10.2147/jhc.s598753

View Full Paper

Ask AI

Bookmark

Share

The Prognostic Value of Circulating Stem Cells Expressing PD-L1 in Patients with Hepatocellular Carcinoma

Key Points

No abstract yet

Implication

Discussion

Cite This Study

The Prognostic Value of Circulating Stem Cells Expressing PD-L1 in Patients with Hepatocellular Carcinoma

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

More related papers

More from Journal of Hepatocellular Carcinoma

Keep reading

More related papers

More from Journal of Hepatocellular Carcinoma