Double Consecutive Paired Electrolysis Enables Dehydroxylative Alkylation of Quinoxalinones with Alcohols

We developed a double-consecutive paired electrolysis system that enables the Minisci-type alkylation of quinoxalinone with alcohols under mild conditions. Using PPh3 as the deoxygenation reagent and iodide as the redox mediator, the direct activation and cleavage of the alcoholic C–O bond were achieved without any preactivation step. Since the electrolysis occurs at the oxidation potential of iodide, which is much lower than that of alcohols, alkyl radicals are thus generated under mild conditions.