Natural products-inspired novel trypanocidal inhibitors and studies towards the total synthesis of pyrronazol A

Key Points

• This research aims to identify new inhibitors against Trypanosoma parasites inspired by natural products and explore the synthesis of pyrronazol A.
• Conducted experiments to test the biological activity of novel trypanocidal inhibitors derived from natural products.
• Developed synthetic pathways toward pyrronazol A to understand its structure-function relationships.
• Identified several novel inhibitors with significant trypanocidal activity against tested parasites.
• Achieved the successful synthesis of pyrronazol A, confirming its structural integrity and potential efficacy.