A Zwitterionic-Enabled One-Pot Electrochemical Strategy for Stable End-Point Detection of Isothermal Nucleic Acid Amplification

Yijie Wang; Yang Li; jiufa zhang; mingjun cai; qi Fu; xiaohan Lin; Cuiping Ma; Chao Shi

doi:10.1039/d6ay00543h

January 1, 2026Analytical Methods

A Zwitterionic-Enabled One-Pot Electrochemical Strategy for Stable End-Point Detection of Isothermal Nucleic Acid Amplification

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Key Points

This research aims to develop a stable electrochemical strategy for detecting nucleic acid amplification.
Utilized a zwitterionic-enabled one-pot strategy in conjunction with loop-mediated isothermal amplification.
Focus on minimizing interfacial fouling to improve signal stability.
Developed an indicator-based electrochemical detection system.
Achieved significant improvements in signal stability during nucleic acid amplification.
Demonstrated successful application in portable nucleic acid testing.

Implication

Demonstrates stable detection of nucleic acid amplification, indicating a breakthrough in portable testing.

Abstract

Indicator-based electrochemical loop-mediated isothermal amplification (EC-LAMP) is highly attractive for portable nucleic acid testing, yet its practical deployment is fundamentally constrained by severe signal instability caused by amplification-induced interfacial fouling....

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea13abe05d6e3efb5fa9b https://doi.org/10.1039/d6ay00543h

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A Zwitterionic-Enabled One-Pot Electrochemical Strategy for Stable End-Point Detection of Isothermal Nucleic Acid Amplification

Key Points

Implication

Abstract

Discussion

Cite This Study

A Zwitterionic-Enabled One-Pot Electrochemical Strategy for Stable End-Point Detection of Isothermal Nucleic Acid Amplification

Key Points

Implication

Abstract

Discussion

Cite This Study

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