PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
May 21, 2026Case Reports in OncologyOpen Access

Accelerated Bilateral Cataract Progression during Olaparib plus Bevacizumab Maintenance Therapy for High-Grade Serous Fallopian Tube Carcinoma: A Case Report

View Full Paper
Ask AI
Bookmark
Share

Authors

WSWataru SaitoKOKuniaki OtaHOHana Okamoto

Discussion

Loading...

Member takes

Overview

Case Report uncovers cataract formation in high-grade serous carcinoma patients during maintenance therapy, suggesting a new ocular toxicity.

Key Points

  • To report a case of accelerated bilateral cataract progression in a patient undergoing olaparib plus bevacizumab therapy.
  • Case report of a 66-year-old woman with high-grade serous carcinoma and BRCA mutation.
  • Neoadjuvant chemotherapy followed by debulking surgery and maintenance therapy with olaparib and bevacizumab.
  • Ophthalmologic evaluations post-treatment to assess cataract development.
  • Patient developed a hypermature cataract in the right eye after three cycles of therapy, requiring surgical intervention.
  • A contralateral mature cataract was identified, becoming symptomatic shortly after right-eye surgery.
  • Postoperative recovery was excellent, but the rapid cataract progression suggests a possible treatment-related effect.

Cite This Study

Saito et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea188be05d6e3efb605c7https://doi.org/10.1159/000551721
View Full Paper
Ask AI
Bookmark
Share