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May 21, 2026Brain Sciences1 citationsOpen Access

Modeling Tumor Microenvironment in Glioblastoma with Organoids

Organoids to Model Tumor Microenvironment in Progression of Pathogenesis and Treatment Resistance in Glioblastoma Multiforme

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Authors

PKPranav KalagaSRSwapan K. Ray

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Overview

Narrative review analyzes organoid technologies to understand tumor behavior and resistance in glioblastoma.

Key Points

  • This review aims to explore the role of organoid technologies in modeling the tumor microenvironment in glioblastoma and understanding treatment resistance.
  • Synthesize recent advances in GBM organoid technologies as three-dimensional modeling systems.
  • Compare various organoid strategies including patient-derived organoids and co-culture systems.
  • Highlight innovations such as spatial transcriptomics and organoid-on-a-chip systems.
  • Organoids better replicate the complex tumor microenvironment compared to traditional models.
  • Innovations in organoids enhance understanding of tumor evolution and therapeutic resistance.
  • Advancements in techniques improve the prospects of precision therapies for glioblastoma.
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Cite This Study

Kalaga et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea196be05d6e3efb6072ahttps://doi.org/10.3390/brainsci16050531
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