Asymmetric Transfer Hydrogenation of gem-Diester-substituted Cyclopropenes Enables the Synthesis of γ-Amino-acid Derivatives and γ-Lactams Bearing Multiple Stereocenters

Aryl/alkyl-substituted cyclopropanes and γ-lactams bearing multiple stereocenters are both important molecular skeletons in chemical synthesis and drug discovery. However, a general method that allows access to both types of compounds...