Effects of neurotoxic lesions of the prelimbic-infralimbic cortex (PL-IL) were examined in rats performing 2 conditional tasks. PL-IL-lesioned rats showed normal acquisition of a visuospatial conditional discrimination in a Y maze as well as a tone-light conditional discrimination in an operant chamber, indicating that the PL-IL is not necessary for response selection processes. When the working memory load was subsequently increased in the tone-light conditional discrimination, rats with PL-IL lesions showed a delay-dependent disruption of performance. This suggests a role of the PL-IL in some working memory processes. However, the present results, considered along with previous studies, suggest that the PL-IL does not seem to be directly involved in the processes necessary to maintain specific items over a delay period but rather in the planning of forthcoming behavioral responses on the basis of previously acquired information.
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Delatour et al. (1999) studied this question.