Key result
Combined myxoma resection and septal myectomy relieves symptoms but causes complete AV block requiring pacing.
Why the study?
The coexistence of cardiac myxoma and hypertrophic cardiomyopathy is exceedingly rare, raising uncertainty regarding the optimal timing of septal reduction therapy when concomitant left ventricular outflow tract obstruction is present.
Case Report (n=1)
Early septal myectomy performed concomitantly with atrial myxoma resection is a viable strategy in young patients with hypertrophic cardiomyopathy, though careful perioperative planning is needed due to the risk of AV block.
Single-case success warrants caution; leaves open need for prospective data on combined myectomy and myxoma resection.
Objective:Rare coexistence of disease or pathology Background:The coexistence of cardiac myxoma and hypertrophic cardiomyopathy is exceedingly rare and poses diagnostic and therapeutic challenges.While atrial myxomas may cause acute hemodynamic compromise, concomitant left ventricular outflow tract obstruction (LVOTO) due to hypertrophic cardiomyopathy can remain clinically underestimated, raising uncertainty regarding the optimal timing of septal reduction therapy. Case Report:A 38-year-old man was admitted with acute dyspnea and hypoxemia.Imaging revealed pulmonary congestion and a large left atrial mass causing functional mitral stenosis.Transthoracic echocardiography demonstrated asymmetric septal hypertrophy (maximum thickness 25 mm) with dynamic LVOTO and a mobile left atrial mass consistent with myxoma.The patient underwent surgical resection of the tumor with concomitant septal myectomy.Histopathology confirmed atrial myxoma and myocardial hyperplasia.Postoperatively, complete atrioventricular block required permanent dual-chamber pacemaker implantation.At short-term follow-up, the patient was asymptomatic with mild residual LVOTO. Conclusions:This case underscores the importance of comprehensive structural and functional assessment in patients with intracardiac tumors.In young patients with favorable prognostic features and significant left atrial dilatation, early septal myectomy performed concomitantly with tumor resection may be justified, even when resting LVOT gradients are below conventional thresholds.This strategy aligns with the latest American and European guidelines on cardiomyopathies and may prevent delayed intervention and disease progression.The case also highlights atrioventricular block as a relevant complication of surgical myectomy, reinforcing the need for careful perioperative planning.Overall, this report provides an instructive example of individualized surgical decisionmaking in complex cardiomyopathy presentations.
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A 2026 study conducted a case report in Cardiac myxoma and hypertrophic cardiomyopathy (n=1). Surgical resection of tumor with concomitant septal myectomy was evaluated. Concomitant surgical resection of an atrial myxoma and septal myectomy in a 38-year-old man with 25 mm septal thickness relieved symptoms but caused complete AV block requiring a pacemaker.
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