Key result
PAF linked to reduced anterior, septal, and lateral LA regional mechanics on 3D cardiac MRI.
Why the study?
Does 3D cardiac MRI detect differences in regional left atrial mechanical function between patients with paroxysmal atrial fibrillation and controls?
Observational (n=18)
Does 3D cardiac MRI detect differences in regional left atrial mechanical function between patients with paroxysmal atrial fibrillation and controls?
Answers are grounded in this paper and cite their sources.
A novel 3D cardiac MRI method demonstrates that left atrial mechanical function is concentrated in anterior, septal, and lateral segments and is significantly reduced in patients with paroxysmal atrial fibrillation.
The left atrium (LA) plays an important role in the maintenance of hemodynamic and electrical stability of the heart. One of the conditions altering the atrial mechanical function is atrial fibrillation (AF), leading to an increased thromboembolic risk due to impaired mechanical function. Preserving the regions of the LA that contribute the greatest to atrial mechanical function during curative strategies for AF is important. The purpose of this study is to introduce a novel method of regional assessment of mechanical function of the LA. We used cardiac MRI to reconstruct the 3D geometry of the LA in nine control and nine patients with paroxysmal atrial fibrillation (PAF). Regional mechanical function of the LA in pre-defined segments of the atrium was calculated using regional ejection fraction and wall velocity. We found significantly greater mechanical function in anterior, septal and lateral segments as opposed to roof and posterior segments, as well as a significant decrease of mechanical function in the PAF group. We suggest that in order to minimize the impact of the AF treatment on global atrial mechanical function, damage related to therapeutic intervention, such as catheter ablation, in those areas should be minimized.
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Kuklik et al. (2014) conducted an observational in Paroxysmal atrial fibrillation (n=18). Cardiac MRI 3D regional mechanics assessment vs. Healthy controls was evaluated on Regional mechanical function of the LA (regional ejection fraction and wall velocity). Cardiac MRI 3D assessment of left atrial regional mechanics demonstrated significantly greater function in anterior, septal, and lateral segments, and a significant decrease in the PAF group.
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