Why the study?
The mechanisms underlying the salutary effects of SGLT2 inhibitors in heart failure have not been fully elucidated, and the specific contribution of ketone bodies requires further clarification.
Design
Review
Key result
SGLT2 inhibitors improve cardiac function in heart failure patients through pleiotropic effects, potentially including optimized energy metabolism via increased ketone body levels.
Authors
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Does not support practice change in HF; leaves open the role of ketone metabolism in SGLT2 inhibitor benefits.
This review discusses the mechanisms underlying the cardiovascular benefits of SGLT2 inhibitors in heart failure, focusing on ketone metabolism, ventricular remodeling, and inflammation.
Saucedo‐Orozco et al. (2022) conducted a review in Heart failure. SGLT2 inhibitors was evaluated. SGLT2 inhibitors improve cardiac function in heart failure patients through pleiotropic effects, potentially including optimized energy metabolism via increased ketone body levels.