Why the study?
What are the primary determinants of functional mitral regurgitation severity in patients with ischemic versus nonischemic dilated cardiomyopathy?
Population
103 patients with functional mitral regurgitation secondary to ischemic cardiomyopathy or nonischemic…
Comparison
Ischemic cardiomyopathy (ICM) vs Nonischemic dilated cardiomyopathy (DCM)
Design
Cohort
Key result
Ischemic cardiomyopathy was associated with more severe functional mitral regurgitation compared to nonischemic dilated cardiomyopathy (mean ERO 0.16 vs 0.12 cm2, P=0.002).
Authors
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May support etiology-specific MR monitoring in cardiomyopathy; leaves open whether coaptation height drives the severity difference.
Observational (n=103)
What are the primary determinants of functional mitral regurgitation severity in patients with ischemic versus nonischemic dilated cardiomyopathy?
Absolute Event Rate: 0.16% vs 0.12%
p-value: p=0.002
Functional mitral regurgitation severity is primarily determined by mitral apparatus deformity, specifically coaptation height, with ischemic cardiomyopathy patients exhibiting more severe MR than nonischemic patients.
Konstantinou et al. (2013) conducted an observational in Functional mitral regurgitation in ischemic and nonischemic dilated cardiomyopathy (n=103). Ischemic cardiomyopathy vs. Nonischemic dilated cardiomyopathy was evaluated on Effective regurgitant orifice (ERO) area (p=0.002). Ischemic cardiomyopathy was associated with more severe functional mitral regurgitation compared to nonischemic dilated cardiomyopathy (mean ERO 0.16 vs 0.12 cm2, P=0.002).