Key result
Male sex was associated with a significantly higher frequency of left ventricular systolic dysfunction compared to female sex in patients with stable angina (25% vs 12%, p<0.005).
Why the study?
Are there age and gender differences in left ventricular function among patients with stable angina compared to healthy controls?
Case-Control (n=725)
Are there age and gender differences in left ventricular function among patients with stable angina compared to healthy controls?
Absolute Event Rate: 25% vs 12%
p-value: p=<0.005
Despite a similar frequency of clinical heart failure, left ventricular systolic dysfunction is more common in men than in women with stable angina.
Suggests sex differences in LV dysfunction among stable angina patients despite similar HF rates; hypothesis-generating and needs prospective confirmation.
To assess left ventricular systolic and diastolic function, M-mode (n = 675) and transmitral Doppler echocardiography (n = 358) were performed in patients with stable angina pectoris and compared with 50 matched healthy controls. Left ventricular fractional shortening (FS) was significantly lower in male than in female patients (32 +/- 7 vs. 35 +/- 7%, p < 0.001). A history of heart failure was as frequent in men (6%) as in women (6%), but left ventricular systolic dysfunction was more frequent in men than in women (25 vs. 12%, p < 0.005). The ratio of early/late diastolic peak flow velocity (E/A ratio) was significantly lower, indicating diastolic dysfunction, in female patients with clinical heart failure than in those without (0.79 +/- 0.25 vs. 1.02 +/- 0.3, p < 0.05). No such difference was found in male patients. Inverse relationships were found between age and E/A ratio in both controls (r = -0.45, p < 0.001) and angina patients (r = -0.44, p < 0.001). Thus, despite similar frequency of clinical heart failure, left ventricular systolic dysfunction was more common in men than in women with stable angina.
No takes yet. Share an insight, caveat, or question.
Eriksson et al. (2008) conducted a case-control in Stable angina pectoris (n=725). Male sex vs. Female sex was evaluated on Left ventricular systolic dysfunction (p=<0.005). Male sex was associated with a significantly higher frequency of left ventricular systolic dysfunction compared to female sex in patients with stable angina (25% vs 12%, p<0.005).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: