Key result
Primary care ECG abnormalities like LBBB are linked to ~244% greater OHCA risk.
Why the study?
Out-of-hospital cardiac arrest is often the first manifestation of unrecognised cardiac disease, and ECG abnormalities encountered in primary care may serve as warning signs.
Are common ECG abnormalities associated with out-of-hospital cardiac arrest in a primary care setting?
Cohort (n=326,227)
Yes
Are common ECG abnormalities associated with out-of-hospital cardiac arrest in a primary care setting?
Common ECG abnormalities obtained in primary care, such as LBBB, non-specific intraventricular block, and ST-depression, are strong predictors of out-of-hospital cardiac arrest.
ECG abnormalities in primary care were associated with higher OHCA risk; hypothesis-generating for risk stratification, prospective validation needed.
Background: Out-of-hospital cardiac arrest (OHCA) is often the first manifestation of unrecognised cardiac disease. ECG abnormalities encountered in primary care settings may be warning signs of OHCA. Objective: We examined the association between common ECG abnormalities and OHCA in a primary care setting. Methods: We cross-linked individuals who had an ECG recording between 2001 and 2011 in a primary care setting with the Danish Cardiac Arrest Registry and identified OHCAs of presumed cardiac cause. Results: A total of 326 227 individuals were included and 2667 (0,8%) suffered an OHCA. In Cox regression analyses, adjusted for age and sex, the following ECG findings were strongly associated with OHCA: ST-depression without concomitant atrial fibrillation (HR 2.79; 95% CI 2.45 to 3.18), left bundle branch block (LBBB; HR 3.44; 95% CI 2.85 to 4.14) and non-specific intraventricular block (NSIB; HR 3.15; 95% CI 2.58 to 3.83). Also associated with OHCA were atrial fibrillation (HR 1.89; 95% CI 1.63 to 2.18), Q-wave (HR 1.75; 95% CI 1.57 to 1.95), Cornell and Sokolow-Lyon criteria for left ventricular hypertrophy (HR 1.56; 95% CI 1.33 to 1.82 and HR 1.27; 95% CI 1.12 to 1.45, respectively), ST-elevation (HR 1.40; 95% CI 1.09 to 1.54) and right bundle branch block (HR 1.29; 95% CI 1.09 to 1.54). The association between ST-depression and OHCA diminished with concomitant atrial fibrillation (HR 1.79; 95% CI 1.42 to 2.24, p < 0.01 for interaction). Among patients suffering from OHCA, without a known cardiac disease at the time of the cardiac arrest, 14.2 % had LBBB, NSIB or ST-depression. Conclusions: Several common ECG findings obtained from a primary care setting are associated with OHCA.
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Søndergaard et al. (2019) conducted a cohort in Out-of-hospital cardiac arrest (n=326,227). Common ECG abnormalities vs. No ECG abnormalities was evaluated on Out-of-hospital cardiac arrest (OHCA) of presumed cardiac cause (HR 3.44, 95% CI 2.85-4.14). Primary care ECG abnormalities like left bundle branch block (HR 3.44; 95% CI 2.85-4.14) and ST-depression (HR 2.79; 95% CI 2.45-3.18) were strongly associated with out-of-hospital cardiac arrest.
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